You may need to have a negative pregnancy test before starting this treatment. If youd like more information about Prolia use during pregnancy or while breastfeeding, talk with your doctor. Do not stop, skip or delay taking Prolia without first talking with your doctor. Your healthcare professional might talk to you about taking a calcium or vitamin D supplement, although generally its better to get enough of each from your diet. If you drink alcohol, talk with your doctor about how much is safe to drink with your condition. Ask your doctor about your own risk. High cholesterol levels can be a side effect of Prolia. What is the most important information I should know about Prolia? What should I know about Prolia vs. Zometa? Visit your doctor or health care professional for regular checks on your progress. Musculoskeletal pain refers to pain in your bones, muscles, tendons, and ligaments. Prolia isnt approved to treat osteopenia or arthritis. It is not known if the use of Prolia over a long period of time may cause slow healing of broken bones. (Hint: it's not just. This increases your risk for bone fractures. According to the American Dental Association, your risk of this problem may increase if you receive denosumab (the active drug in Prolia) for longer than 2 years. Prolia may cause several side effects. It could harm the unborn baby or cause birth defects. Another common osteoporosis medication is denosumab (Prolia, Xgeva). While youre receiving Prolia treatment, your doctor will monitor your cholesterol levels with regular blood tests. If you plan to drink alcohol while using Prolia, ask your doctor how much is safe to drink. (BMD is a measurement of the amount of minerals such as calcium in your bones.) No, weight gain wasnt reported as a side effect of Prolia in clinical trials. Prolia should not be used during pregnancy. To learn how Prolia and Tymlos are alike and different, see this comparison. The list below may not include all possible serious side effects of the drug. Last updated on Feb 8, 2023. have low blood calcium; or are pregnant or plan to become pregnant, as Prolia may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia. People administered concomitant immunosuppressant agents (such as prednisone or cyclosporine) or with impaired immune systems may be at an even higher risk. It blocks the effects of certain bone cells called osteoclasts in breaking down bone tissue. Will my fracture risk come back if I stop Prolia treatment? Had parathyroid or thyroid surgery (glands located in your neck), Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome), Have kidney problems or are on kidney dialysis, Are taking medicine that can lower your blood calcium levels, Plan to have dental surgery or teeth removed, Are breast-feeding or plan to breast-feed. Call your doctor right away if you have signs of infection such as: swelling, pain, tenderness, warmth, or redness anywhere on your body; pain and burning when you urinate, painful urination; bladder infection (painful or difficult urination); lung infection (cough, shortness of breath); cold symptoms such as stuffy nose, sneezing, sore throat; This is not a complete list of side effects and others may occur. The study uses data from the FDA. Prolia is a prescription medicine used to treat bone loss in men who are at high risk for fracture receiving certain treatments So be sure to talk with your doctor about any past or upcoming surgery before starting treatment with the drug. Follow your doctor's instructions about any restrictions on food, beverages, or activity. Different individuals may respond to medication in different ways. Vertigo (dizziness) was reported in some people who received Prolia for osteoporosis, but this was a less common side effect. Prolia is also available in a biosimilar form. Copyright 2023 Elsevier Inc. All Rights Reserved. The most common medications prescribed to lower cholesterol are statins. Stopping some drugs leads to withdrawal symptoms because your body is used to the drug and needs it for you to feel normal. Coral calcium is also used in maxillofacial surgery and bone grafting. For Prolia, talk to your pediatrician regarding the use of this medicine in children. Store in the original container away from heat and light. Is the ketogenic diet right for autoimmune conditions? To see a side-by-side comparison of Prolia and Fosamax, view this drug article. Prolia pregnancy and breastfeeding warnings. Prolia is a prescription medicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments Now i am worried that i've been taking K2 which also takes calcium from the blood to the bones. If you have questions about how to pay for your prescription, talk with your doctor or pharmacist. This may include acetaminophen (Tylenol), naproxen (Aleve), or ibuprofen (Advil, Motrin). You can use the study as a second opinion to make health care decisions. * Sex and gender exist on spectrums. Drug class: Miscellaneous bone resorption inhibitors. The ADA also provides recommendations to help your dentist in reducing your risk for these side effects while youre taking Prolia. Both medications are approved to treat certain people with osteoporosis, as well as people with other conditions. Prolia is a prescription medicine used to increase bone mass in men with osteoporosis who are at high risk for fracture. For a basic overview of Prolia, including details about its uses, see this article. Find out what it means, how its calculated, and more. Before taking Prolia, tell your doctor about all of your medical conditions, including if you: Your healthcare provider should do a pregnancy test before you start treatment with Prolia. Tingling or numbness in the hands, feet, and face can develop as a symptom of severe hypocalcemia. If you have a low calcium level, you should not take Prolia. If youve had surgery on your thyroid or parathyroid glands, you may have an increased risk of a low level of calcium in your blood. MNT is the registered trade mark of Healthline Media. Prolia is a prescription medicine used to treat bone loss in men who are at high risk for fracture receiving certain treatments for prostate cancer that has not spread to other parts of the body. Biosimilars usually cost less than brand-name drugs. Call your doctor at once if you have: new or unusual pain in your thigh, hip, or groin; severe pain in your joints, muscles, or bones; skin problems such as dryness, peeling, redness, itching, blisters, bumps, oozing, or crusting; or. These are not all the possible side effects of Prolia. And some of these side effects are more common with certain uses of Prolia. See your dentist regularly. Generic name: denosumab (Prolia) [den-OH-sue-mab] Before beginning treatment with Prolia, ask your doctor about the benefits and risks of the drug. Do not reuse a needle or syringe. It comes as a liquid solution thats given as an injection. If your doctor says this is safe for you, youll be shown how to inject the medication. If youve already gone through menopause, your risk for bone loss is increased. They can explain the risks and benefits of this drug. You may also want to do some research on your own. You should always consult your doctor or another healthcare professional before taking any medication. You may wonder how Prolia compares to the medication Zometa. If you receive Prolia, you should not receive XGEVA. Do not share this medicine with another person, even if they have the same symptoms you have. A special MedGuide will be given to you before each treatment. They can also happen if you have certain conditions or if you take certain medications. In rare cases, your doctor may have you self-inject Prolia at home. Talk with your doctor about which other treatments are better choices for you. Studies of Prolia didnt report weight gain as a side effect of the drug. It is based on denosumab and calcium (the active ingredients of Prolia and Calcium, respectively), and Prolia and Calcium (the brand names). Based on your dental history, your doctor can discuss with you the risks of using Prolia. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of your face, lips, or tongue; rash; itching; or hives. (Biosimilars are like generic drugs. You should receive your missed injection as soon as possible. For more information on this side effect, see Side effect specifics below. Talk with your doctor about the risks of using this drug during pregnancy. Youll receive Prolia from a healthcare professional as an injection under the skin in one of the following areas: Prolia contains the active drug denosumab, which is a biologic medication. In fact, bone breakdown is higher in the first several months after you stop Prolia. Examples of conditions Prolia is used off-label to treat include: Prolia is one option available to treat osteoporosis and reduce bone loss in people with a high risk for bone fracture. Your doctor may suggest limiting foods that are high in trans fats, such as fried foods. In addition, Prolia may also be used off-label for other conditions that cause bone loss or loss of bone mineral density. The most common side effects of Prolia in men with osteoporosis are back pain, joint pain, and common cold (runny nose or sore throat). Denosumab is contraindicated in women with hypocalcaemia. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. But they each work differently because Prolia is a monoclonal antibody (it may also be called a miscellaneous bone resorption agent) and Reclast is a bisphosphonate which means they have different side effects, other uses, tolerability, and effectiveness profiles. Learn more about some of the side effects Prolia may cause. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. Side effects that you should report to your doctor or health care professional as soon as possible: Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): This list may not describe all possible side effects. They may help you identify other possible causes or suggest ways to help manage hair loss. What are the possible side effects of Prolia? Youll get Prolia injections from a healthcare professional once every 6 months. You should also talk with your doctor if you have nausea during treatment. Its recommended that calcium and vitamin D supplements be taken Prolia is meant to be used in combination with calcium and vitamin D supplements. But weight gain may be a symptom of a side effect called peripheral edema. Your doctor can provide more information to you about the benefits and risks of using Prolia for your condition. * Symptoms can include: flushing (temporary warmth, redness, or deepening of skin color), swelling under your skin, typically in your lips, eyelids, feet, or hands, swelling of your mouth, tongue, or throat, which can make it hard to breathe. You should not receive Prolia if you are allergic to denosumab, or if you have: low levels of calcium in your blood (hypocalcemia); or. Do not treat yourself. To learn about other mild side effects, talk with your doctor or pharmacist, or read Prolias medication guide. What should I know about Prolia vs. Reclast? Below are answers to some commonly asked questions about Prolia. Learn how estrogen affects bone health and how you can protect yourself from bone loss, Osteoporosis is more common in women than men, but it affects millions of men every year. It can have some side effects, but these may depend on who uses it. Now i'm wondering if i shouldn't take K2. Patient testimonials represent individual experiences with Prolia. A severe jawbone problem called osteonecrosis has rarely been reported with Prolia. Tell them if you have any scheduled dental work coming up. Before you receive Prolia, tell your doctor if you have kidney disease (or if you are on dialysis), a weak immune system, a history of hypoparathyroidism or thyroid surgery, a history of intestinal surgery, a condition that makes it hard for your body to absorb nutrients from food, or if you are allergic to latex. Keep in mind that Prolia is used to help strengthen your bones and prevent fractures, which may happen with falls. Dizziness from Prolia is usually mild and may go away on its own within a few days or weeks. Take only the amount of calcium and vitamin D that your doctor has prescribed. There is a potential for serious side effects to an unborn child. Continue reading, Prolia is a prescription medicine injected under the skin (called a subcutaneous injection) and is given once every 6 months. For example, an over-the-counter pain reliever can often ease mild pain such as joint or muscle pain, or headache. Ask your doctor about the pros and cons of using Prolia. pain in bones and muscles, including back, arm, and leg pain, pain or swelling in the thigh or groin area. Special care may be needed. Continue reading, Yes, Prolia does appear to weaken your immune system. Get the treatment that fits your lifestyle, Stay informed with courtesy reminders, recipes and so much more. We do not endorse non-Cleveland Clinic products or services. You should also ask your doctor if Prolia is safe for you if you have or have had: Additionally, let your doctor know if youre pregnant or breastfeeding. Like most drugs, Prolia may cause mild or serious side effects. (Chlorhexidine helps kill germs in your mouth.). But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. Prolia was the right choice for me because it worked for me and it was 1 shot every 6 months. You should take calcium and vitamin D as your doctor tells you to while you receive Prolia. Vertigo (dizziness) was reported in some females* using Prolia for osteoporosis. Hair loss wasnt reported as a side effect during clinical trials of Prolia. The drug attaches to the RANK protein and helps prevent osteoclasts from breaking down bone. Boniva contains the active drug ibandronate, but Prolia contains the active drug denosumab. These side effects may include: Its not known what percentage of people in clinical trials developed dental or jaw-related side effects. Compared to other osteoporosis treatments, only Proliais1 shot every 6 months. And in my mind, that's no different than scheduling a visit to the dentist twice a year. Other side effects may continue for as long as you receive the medication, but they can often be relieved with other treatments. The two most common forms of arthritis are osteoarthritis and rheumatoid arthritis (RA). This means your bones may be weaker than usual. Learn strategies you can use today. WebDrug interactions are reported among people who take Prolia and Calcium. Tell your doctor if you become pregnant. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. All rights reserved. (To learn more, see the Precautions for Prolia section below.). * Sex and gender exist on spectrums. All information is observation-only. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Your doctor can also advise you on symptoms of low calcium to look for. Youll likely receive Prolia long term if you and your doctor decide that the drug is effective and safe for you. Prolias manufacturer also provides some self-injection instructions, as well as a video to show you how to inject Prolia. Muscle pain often contributes to back pain, one of the most common side effects reported in clinical trials of Prolia.
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