The average age of participants was 60.8 years, and 92.0% were White. COVID-NET conducts population-based surveillance for laboratory-confirmed COVID-19associated hospitalizations in 99 counties across 14 states. COVID-19associated hospitalizations are those occurring among residents of a predefined surveillance catchment area who have a positive real-time reverse transcriptionpolymerase chain reaction (RT-PCR) or rapid antigen detection test result for SARS-CoV-2 during hospitalization or the 14 days preceding admission. However, infants aged <6 months are not currently eligible for any currently available COVID-19 vaccines and must rely on placentally acquired immunity from their mothers. Iowa does not provide data on vaccination status. The aim of the secondary design was to compare the results of the cohort with TND. NMF, MC, GD, DDA, AMP, and ST handled project administration. This preceded and had no relation to COVID-19, and GD had no role in and received no funding from the project. Another explanation is the presence of a high COVID-19 vaccination rate among studied individuals (more than two-thirds), which is supported by the finding that the majority of patients had been infected with SARS-CoV-2 prior to undergoing vaccination. Effectiveness of COVID-19 vaccines in preventing hospitalization among adults aged 65 yearsCOVID-NET, 13 states, FebruaryApril 2021. 384, 403416 (2021). Article Data among adults over 50 showed that a booster shot gave even stronger protection. By comparison, from two to 25 weeks after the second dose, protection against Omicron hospitalization was 64%, the UKHSA said. 189, 13791388 (2020). Background: Risk stratification models have been developed to identify patients that are at a higher risk of COVID-19 infection and severe illness. The outcomes were the infants first positive nasal/throat swab for SARS-CoV-2 by PCR, and the first COVID-19-related hospitalization, occurring during the first 6 months of life and recorded in the electronic health record. PubMed We were not able to evaluate more detailed measures of relative clinical severity in hospitalised patients (such as intensive care unit admittance), but our finding that estimated severity reductions comparing omicron with delta are larger for more severe endpoints (death and hospital admission versus hospital attendance) agrees with observations that the proportion of hospitalised COVID-19 patients requiring intensive care or mechanical ventilation (or both) has been substantially lower during the omicron wave in England than the preceding delta wave. T.R. This analysis describes weekly hospitalization rates during Delta- and Omicron-predominant periods. Centers for Disease Control and Prevention. Data about boosters was only available for those over 50. CDC is not responsible for the content and B.F. P.R. However, these Omicron impacts have been mostly observed in countries with high vaccination rates in the Region: the comparatively lower rate of hospitalizations and deaths so far is in large part thanks to vaccination, particularly of vulnerable groups. and statistical significance was assessed at two-sided p0.05. If material is not included in the articles Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. These cookies may also be used for advertising purposes by these third parties. In our primary analysis, we implemented a cohort study design where we used Cox proportional hazards models that allow for time-varying covariates to estimate the SARS-CoV-2 infection hazard ratio (HR) in infants of mothers vaccinated with at least 2 doses of mRNA COVID-19 vaccines during pregnancy and 1 dose only versus mothers who were unvaccinated during pregnancy. Rep. 7, 255263 (2022). Members receive almost all their medical care at KPNC-owned facilities, including clinics, hospitals, pharmacies, and laboratories. Delta period: July 1, 2021December 18, 2021, reflects the time when Delta was the predominant circulating variant; Omicron period: December 19, 2021January 31, 2022, reflects the time when Omicron was the predominant circulating variant. National influenza and COVID-19 surveillance report: 27 January 2022 (week 4). Vaccinated patients were older (68 vs. 57 years), and 62% had at least one comorbidity Admission to the ICU was 20%, and the mortality rate at 30 days was 14%. Implementing strategies that result in the equitable receipt of COVID-19 vaccinations, though building vaccine confidence, raising awareness of the benefits of vaccination, and removing barriers to vaccination access among persons with disproportionately higher hospitalizations rates from COVID-19, including Black adults, is an urgent public health priority. You are using a browser version with limited support for CSS. Vaccines and Omicron mean Covid now less deadly than flu in England 383, 26032615 (2020). Among these infants, for our main analysis, we excluded 21,891 (35.2%) based on maternal exclusion criteria and 10,412 (16.8%) after applying infant exclusion criteria (Fig. Most mothers (66.14%) were between ages 25 and <35 years, and more than a quarter (27.27%) were of Asian race, 5.16% were Black, 24.44% were of Hispanic ethnicity and 37.57% were White. In supplemental analyses by trimester of vaccination, receipt of the second dose during the second and third trimesters reduced the risk of infants testing SARS-CoV-2 positive during the Delta dominant period by 91% (95% CI: 63, 98) and 85% (95% CI: 50, 96), respectively, during the first 2 months of life, by 59% (95% CI: 21, 79) and 67% (95% CI: 37, 83) during the first 4 months of life and by 64% (95% CI:31, 81) and 53% (95% CI: 24, 71) during the first 6 months of life. There were only one hospitalized case among the children of vaccinated mothers and nine hospitalized cases among the children of unvaccinated mothers (Table1). Taken together, these findings suggest that the increased risk for hospitalization among Black adults during the Omicron-predominant period might also be due, in part, to lower proportions of Black adults receiving both the primary vaccination series and booster doses. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. These trends could result in epidemic phase bias if infection severity is correlated with time from infection to test. It is possible that our exclusion criteria may have resulted in a final sample that may not be reflective of all KPNC infants. * Data are from a weighted sample of hospitalized nonpregnant adults with completed medical record abstractions and a discharge disposition. Open 5, e2232760 (2022). Thank you for visiting nature.com. J. Med. COVID hospitalizations amid omicron 23 times higher among - ABC News Users are referred to the electronic PDF version (https://www.cdc.gov/mmwr) IMV status was missing in 1.4% (weighted) of hospitalizations; these hospitalizations are otherwise included elsewhere in the analysis. During the Delta period, we found that protection extended through the infants first 6 months of life. Adults with no documented receipt of any COVID-19 vaccine dose before the test date were considered unvaccinated. Mortal. Characteristics and maternal and birth outcomes of hospitalized pregnant women with laboratory-confirmed COVID-19COVID-NET, 13 states, March 1August 22, 2020. Relative to the Delta-predominant period, the proportion of cases in non-Hispanic Asian or Pacific Islanders also increased, whereas the proportion in all other racial and ethnic groups decreased. Acosta AM, Garg S, Pham H, et al. J. Med. part 56; 42 U.S.C. The proportion of hospitalized adults who received booster or additional doses increased from 1.3% during the Delta-predominant period to 13.4% during the Omicron-predominant period (p<0.01)***; among these, 10.7% were long-term care facility residents and 69.5% had an immunosuppressive condition. Black adults accounted for 25.2% of all unvaccinated persons hospitalized during the Delta-predominant period; that proportion increased by 23%, to 31.0% during the Omicron-predominant period. Hobbs, C. V. et al. COVID is still killing people every day. But its main victims have Zerbo, O., Ray, G.T., Fireman, B. et al. Individual and neighborhood factors associated with failure to vaccinate against influenza during pregnancy. Saving Lives, Protecting People, https://covid.cdc.gov/covid-data-tracker/#variant-proportions, https://www.cdc.gov/coronavirus/2019-ncov/covid-data/covid-net/purpose-methods.html, https://www.cdc.gov/mmwr/volumes/69/wr/mm6915e3.htm, https://www.cdc.gov/nchs/nvss/bridged_race.htm, https://www.medrxiv.org/content/10.1101/2021.08.27.21262356v1, https://www.cdc.gov/mmwr/volumes/70/wr/mm7050e2.htm, https://www.nejm.org/doi/full/10.1056/NEJMoa2114255, https://medrxiv.org/cgi/content/short/2021.08.27.21262356v1, https://www.medrxiv.org/content/10.1101/2022.01.11.22269045v1, https://data.cdc.gov/Vaccinations/COVID-19-Vaccination-Demographics-in-the-United-St/km4m-vcsb, https://www.cdc.gov/coronavirus/2019-ncov/vaccines/stay-up-to-date.html, https://doi.org/10.1001/jamanetworkopen.2021.30479, Centers for Disease Control and Prevention, U.S. Department of Health & Human Services, American Indian or Alaska Native, non-Hispanic, Psychiatric admission requiring medical care. Monthly COVID-19 hospitalization rates were 3.5 to 17.7 times higher in unvaccinated patients than in their vaccinated counterparts, regardless of whether they had received a booster. The vaccines have proved highly safe and effective at reducing the risk of severe illness, hospitalization and death. Risk of reinfection, vaccine protection, and severity of infection with In this primary design, all eligible infants meeting inclusion criteria were included without sampling which improved power and minimized bias related to selection. Estimated Effectiveness of COVID-19 Vaccines Against Omicron or Delta Mortal. The University of Minnesota is an equal opportunity educator and employer, Office of the Vice President for Research | Contact U of M | Privacy Policy, Mary Van Beusekom | News Writer | CIDRAP News, Two recent papers claim there are no differences between surgical masks and respirators for preventing the spread of respiratory diseases like COVID-19 and flu, but the articles. Vaccination status is based on state immunization information system data. Includes current treatment or recent diagnosis of an immunosuppressive condition or use of an immunosuppressive therapy during the preceding 12 months.
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